Drug interactions
Quizartinib + Sunitinib
Severity: Major
Quizartinib and Sunitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval and sunitinib also carries QT risk. The combination may increase the risk of torsades de pointes and sudden death.
What this interaction means in plain words
Quizartinib and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quizartinib belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG frequently and keep electrolytes normal. Reduce or interrupt quizartinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Quizartinib and Sunitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Quizartinib with Sunitinib?
MediHelp rates the interaction as major. Quizartinib and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval and sunitinib also carries QT risk. The combination may increase the risk of torsades de pointes and sudden death.
How serious is the interaction between Quizartinib and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG frequently and keep electrolytes normal. Reduce or interrupt quizartinib if QTc becomes markedly prolonged.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
