Drug interactions
Quizartinib + Telavancin
Severity: Major
Quizartinib and Telavancin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib causes marked, dose-related QT prolongation and has a boxed warning for torsades de pointes. Telavancin may add to the QTc lengthening, which could increase the risk of life-threatening arrhythmia.
What this interaction means in plain words
Quizartinib and Telavancin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quizartinib belongs to Oncology; Telavancin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if an alternative antibacterial is available. If it is unavoidable, monitor ECG more frequently, maintain normal potassium and magnesium, and reduce the quizartinib dose or interrupt it as the labeling directs when the QTc lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Quizartinib with Telavancin?
MediHelp rates the interaction as major. Quizartinib and Telavancin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib causes marked, dose-related QT prolongation and has a boxed warning for torsades de pointes. Telavancin may add to the QTc lengthening, which could increase the risk of life-threatening arrhythmia.
How serious is the interaction between Quizartinib and Telavancin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antibacterial is available. If it is unavoidable, monitor ECG more frequently, maintain normal potassium and magnesium, and reduce the quizartinib dose or interrupt it as the labeling directs when the QTc lengthens.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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