Drug interactions
Rabeprazole + Tazemetostat
Severity: Minor
Rabeprazole and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and a CYP3A substrate, while rabeprazole is not a meaningful CYP3A4 inhibitor. No clinically significant change in either drug is expected.
What this interaction means in plain words
Rabeprazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tazemetostat affects a minor pathway of rabeprazole; rabeprazole has no meaningful effect on tazemetostat metabolism.
What to do
No dose adjustment is needed. Monitor clinical response to both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Rabeprazole with Tazemetostat?
MediHelp rates the interaction as minor. Rabeprazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and a CYP3A substrate, while rabeprazole is not a meaningful CYP3A4 inhibitor. No clinically significant change in either drug is expected.
How serious is the interaction between Rabeprazole and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor clinical response to both drugs.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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