Drug interactions
Rabeprazole + Tecovirimat
Severity: Minor
Rabeprazole and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP2C19 inhibitor and weak CYP3A4 inducer, so effects on rabeprazole are small and opposing. Rabeprazole clearance is mostly non-enzymatic, so a clinically relevant change is unlikely.
What this interaction means in plain words
Rabeprazole and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP2C19 inhibition and CYP3A4 induction by tecovirimat influence minor pathways of rabeprazole metabolism.
What to do
No dose adjustment is needed. Monitor for PPI adverse effects or loss of acid control during the short tecovirimat course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Rabeprazole with Tecovirimat?
MediHelp rates the interaction as minor. Rabeprazole and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP2C19 inhibitor and weak CYP3A4 inducer, so effects on rabeprazole are small and opposing. Rabeprazole clearance is mostly non-enzymatic, so a clinically relevant change is unlikely.
How serious is the interaction between Rabeprazole and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for PPI adverse effects or loss of acid control during the short tecovirimat course.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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