Drug interactions
Rabies vaccine + Sirolimus
Severity: Moderate
Rabies vaccine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression with sirolimus may produce an inadequate rabies antibody response, which is important when the vaccine is used for post-exposure prophylaxis. The vaccine is inactivated and not unsafe.
What this interaction means in plain words
Rabies vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sirolimus suppresses T- and B-cell proliferation through mTOR inhibition, weakening vaccine-induced immunity.
What to do
Give the vaccine when indicated and check rabies neutralizing antibody titers afterward in immunosuppressed patients. Use immune globulin as per post-exposure guidelines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rabies vaccine and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Rabies vaccine with Sirolimus?
MediHelp rates the interaction as moderate. Rabies vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression with sirolimus may produce an inadequate rabies antibody response, which is important when the vaccine is used for post-exposure prophylaxis. The vaccine is inactivated and not unsafe.
How serious is the interaction between Rabies vaccine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine when indicated and check rabies neutralizing antibody titers afterward in immunosuppressed patients. Use immune globulin as per post-exposure guidelines.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
