Drug interactions
Rabies vaccine chick embryo cell derived + Sirolimus
Severity: Moderate
Rabies vaccine chick embryo cell derived and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may reduce the antibody response to this inactivated rabies vaccine, potentially leaving the patient inadequately protected. The vaccine is not live and carries no added infection risk.
What this interaction means in plain words
Rabies vaccine chick embryo cell derived and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sirolimus suppresses T- and B-cell proliferation through mTOR inhibition, weakening vaccine-induced immunity.
What to do
Vaccinate when indicated and confirm seroconversion with rabies neutralizing antibody testing. Follow post-exposure guidance, including immune globulin where applicable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Rabies vaccine chick embryo cell derived with Sirolimus?
MediHelp rates the interaction as moderate. Rabies vaccine chick embryo cell derived and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may reduce the antibody response to this inactivated rabies vaccine, potentially leaving the patient inadequately protected. The vaccine is not live and carries no added infection risk.
How serious is the interaction between Rabies vaccine chick embryo cell derived and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated and confirm seroconversion with rabies neutralizing antibody testing. Follow post-exposure guidance, including immune globulin where applicable.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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