Drug interactions
Rabies vaccine chick embryo cell derived + Tacrolimus
Severity: Major
Rabies vaccine chick embryo cell derived and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may blunt the immune response to the inactivated rabies vaccine. Because rabies is fatal, an inadequate response is clinically important.
What this interaction means in plain words
Rabies vaccine chick embryo cell derived and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Calcineurin inhibition suppresses T-cell dependent antibody production.
What to do
Give the complete series and immunoglobulin when exposure has occurred, then measure neutralizing antibody titers. Do not delay post-exposure prophylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rabies vaccine chick embryo cell derived and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Rabies vaccine chick embryo cell derived with Tacrolimus?
MediHelp rates the interaction as major. Rabies vaccine chick embryo cell derived and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tacrolimus may blunt the immune response to the inactivated rabies vaccine. Because rabies is fatal, an inadequate response is clinically important.
How serious is the interaction between Rabies vaccine chick embryo cell derived and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the complete series and immunoglobulin when exposure has occurred, then measure neutralizing antibody titers. Do not delay post-exposure prophylaxis.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
