Drug interactions
Ramipril + Voclosporin
Severity: Moderate
Ramipril and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can reduce glomerular filtration and raise serum potassium. Combined with ramipril, there is an increased risk of hyperkalemia and renal function decline.
What this interaction means in plain words
Ramipril and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramipril belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor afferent vasoconstriction and reduced tubular potassium secretion add to ACE inhibitor effects on efferent tone and aldosterone.
What to do
Monitor serum potassium and eGFR regularly, particularly after starting or changing doses. Adjust voclosporin per labeling if eGFR falls and treat hyperkalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ramipril with Voclosporin?
MediHelp rates the interaction as moderate. Ramipril and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can reduce glomerular filtration and raise serum potassium. Combined with ramipril, there is an increased risk of hyperkalemia and renal function decline.
How serious is the interaction between Ramipril and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR regularly, particularly after starting or changing doses. Adjust voclosporin per labeling if eGFR falls and treat hyperkalemia promptly.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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