Drug interactions
Rapacuronium + Succinylcholine
Severity: Moderate
Rapacuronium and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Giving succinylcholine before a non-depolarizing blocker can alter the onset and depth of the second blocker's effect. Rapacuronium has been withdrawn from most markets because of severe bronchospasm.
What this interaction means in plain words
Rapacuronium and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic interaction at the neuromuscular junction between a depolarizing and a non-depolarizing blocker.
What to do
If both are used, wait for recovery from succinylcholine before giving the non-depolarizing agent and monitor with a nerve stimulator. Consider another non-depolarizing agent given rapacuronium's bronchospasm risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Succinylcholine
Frequently asked questions
Can I take Rapacuronium with Succinylcholine?
MediHelp rates the interaction as moderate. Rapacuronium and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Giving succinylcholine before a non-depolarizing blocker can alter the onset and depth of the second blocker's effect. Rapacuronium has been withdrawn from most markets because of severe bronchospasm.
How serious is the interaction between Rapacuronium and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are used, wait for recovery from succinylcholine before giving the non-depolarizing agent and monitor with a nerve stimulator. Consider another non-depolarizing agent given rapacuronium's bronchospasm risk.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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