Drug interactions
Rasagiline + Saxagliptin-metformin
Severity: Minor
Rasagiline and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may lower blood glucose and increase the effect of antidiabetic drugs, although selective MAO-B inhibition at rasagiline doses makes this less likely. Clinical significance is expected to be small.
What this interaction means in plain words
Rasagiline and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rasagiline belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Possible additive glucose lowering; mechanism not firmly established.
What to do
No routine change needed; check glucose if symptoms of hypoglycemia occur after starting rasagiline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Rasagiline and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors may lower blood glucose and increase the effect of antidiabetic drugs, although selective MAO-B inhibition at rasagiline doses makes this less likely. Clinical significance is expected to be small.
How serious is the interaction between Rasagiline and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; check glucose if symptoms of hypoglycemia occur after starting rasagiline.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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