Drug interactions
Rasagiline + Sufentanil
Severity: Major
Rasagiline and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids given with MAO inhibitors may cause CNS and respiratory depression, hypotension, or occasionally serotonin syndrome. Sufentanil has weaker serotonergic activity than some opioids, but caution is still needed.
What this interaction means in plain words
Rasagiline and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rasagiline belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with possible serotonergic toxicity from interaction of opioids with MAO inhibition.
What to do
Avoid within 14 days of an MAO inhibitor when possible. If sufentanil is essential, use reduced initial doses with careful titration and monitor respiration, blood pressure and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Rasagiline with Sufentanil?
MediHelp rates the interaction as major. Rasagiline and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids given with MAO inhibitors may cause CNS and respiratory depression, hypotension, or occasionally serotonin syndrome. Sufentanil has weaker serotonergic activity than some opioids, but caution is still needed.
How serious is the interaction between Rasagiline and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid within 14 days of an MAO inhibitor when possible. If sufentanil is essential, use reduced initial doses with careful titration and monitor respiration, blood pressure and signs of serotonin toxicity.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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