Drug interactions
Rasagiline + Sumatriptan
Severity: Moderate
Rasagiline and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is metabolized by MAO-A, and combined serotonergic activity raises serotonin syndrome concern. Rasagiline's MAO-B selectivity at recommended doses limits the pharmacokinetic effect.
What this interaction means in plain words
Rasagiline and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rasagiline belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects and possible reduced triptan metabolism via MAO inhibition.
What to do
Use the lowest effective sumatriptan dose and monitor for serotonin toxicity. Consider an alternative migraine therapy if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Rasagiline with Sumatriptan?
MediHelp rates the interaction as moderate. Rasagiline and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sumatriptan is metabolized by MAO-A, and combined serotonergic activity raises serotonin syndrome concern. Rasagiline's MAO-B selectivity at recommended doses limits the pharmacokinetic effect.
How serious is the interaction between Rasagiline and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sumatriptan dose and monitor for serotonin toxicity. Consider an alternative migraine therapy if symptoms occur.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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