Drug interactions
Rasagiline + Tetrabenazine
Severity: Contraindicated
Rasagiline and Tetrabenazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine is contraindicated with MAO inhibitors because of the risk of hypertensive reactions. A 14-day gap is recommended after stopping an MAO inhibitor.
What this interaction means in plain words
Rasagiline and Tetrabenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rasagiline belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Tetrabenazine depletes vesicular monoamines, and MAO inhibition prevents degradation of released catecholamines, causing hypertension.
What to do
Do not co-administer; allow at least 14 days between stopping an MAO inhibitor and starting tetrabenazine. Review the choice of Parkinson disease or chorea therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Rasagiline with Tetrabenazine?
MediHelp rates the interaction as contraindicated. Rasagiline and Tetrabenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tetrabenazine is contraindicated with MAO inhibitors because of the risk of hypertensive reactions. A 14-day gap is recommended after stopping an MAO inhibitor.
How serious is the interaction between Rasagiline and Tetrabenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days between stopping an MAO inhibitor and starting tetrabenazine. Review the choice of Parkinson disease or chorea therapy.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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