Drug interactions
Rasagiline + Tranylcypromine
Severity: Contraindicated
Rasagiline and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding rasagiline to tranylcypromine can cause loss of MAO-B selectivity and additive MAO inhibition, risking hypertensive crisis and serotonin syndrome. Labeling prohibits use together.
What this interaction means in plain words
Rasagiline and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rasagiline belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive inhibition of MAO-A and MAO-B causes excessive monoamine accumulation.
What to do
Avoid concurrent use. Allow at least 14 days between stopping one agent and starting the other.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Rasagiline and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Adding rasagiline to tranylcypromine can cause loss of MAO-B selectivity and additive MAO inhibition, risking hypertensive crisis and serotonin syndrome. Labeling prohibits use together.
How serious is the interaction between Rasagiline and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Allow at least 14 days between stopping one agent and starting the other.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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