Drug interactions
Ravulizumab + Upadacitinib
Severity: Major
Ravulizumab and Upadacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ravulizumab blocks terminal complement C5, predisposing to serious meningococcal infection. Upadacitinib adds general immunosuppression, which may further increase infection risk.
What this interaction means in plain words
Ravulizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ravulizumab belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from terminal complement blockade and JAK inhibition.
What to do
Confirm meningococcal vaccination and consider antibiotic prophylaxis per labeling; monitor for early signs of infection. Use together only when clearly needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Ravulizumab
- Crovalimab + Ravulizumab Major
Frequently asked questions
Can I take Ravulizumab with Upadacitinib?
MediHelp rates the interaction as major. Ravulizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ravulizumab blocks terminal complement C5, predisposing to serious meningococcal infection. Upadacitinib adds general immunosuppression, which may further increase infection risk.
How serious is the interaction between Ravulizumab and Upadacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm meningococcal vaccination and consider antibiotic prophylaxis per labeling; monitor for early signs of infection. Use together only when clearly needed.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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