Drug interactions
Regorafenib + Rifabutin
Severity: Major
Regorafenib and Rifabutin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and can lower regorafenib exposure, possibly reducing efficacy. Active metabolite M-5 exposure may rise with strong inducers.
What this interaction means in plain words
Regorafenib and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Regorafenib belongs to Oncology; Rifabutin belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by rifabutin increases regorafenib clearance.
What to do
Avoid concomitant use and choose an alternative with no or weak CYP3A4 induction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Regorafenib
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Regorafenib with Rifabutin?
MediHelp rates the interaction as major. Regorafenib and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifabutin induces CYP3A4 and can lower regorafenib exposure, possibly reducing efficacy. Active metabolite M-5 exposure may rise with strong inducers.
How serious is the interaction between Regorafenib and Rifabutin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose an alternative with no or weak CYP3A4 induction.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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