Drug interactions
Regorafenib + Sofosbuvir-velpatasvir
Severity: Moderate
Regorafenib and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP and raise exposure to BCRP substrates such as sofosbuvir and velpatasvir. Clinical significance is uncertain.
What this interaction means in plain words
Regorafenib and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Regorafenib is predicted to inhibit BCRP efflux.
What to do
Monitor for antiviral adverse effects and regorafenib hepatotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Regorafenib and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP and raise exposure to BCRP substrates such as sofosbuvir and velpatasvir. Clinical significance is uncertain.
How serious is the interaction between Regorafenib and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antiviral adverse effects and regorafenib hepatotoxicity.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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