Drug interactions
Remifentanil + Selinexor
Severity: Moderate
Remifentanil and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, fatigue and confusion, and an opioid may worsen these CNS effects. The interaction is pharmacodynamic and incompletely studied.
What this interaction means in plain words
Remifentanil and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Remifentanil belongs to Musculoskeletal; Selinexor belongs to Oncology.
Why it happens
Additive CNS effects; the mechanism of selinexor neurotoxicity is not well established.
What to do
Monitor for sedation, confusion and falls, and use the lowest effective remifentanil dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Remifentanil with Selinexor?
MediHelp rates the interaction as moderate. Remifentanil and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, fatigue and confusion, and an opioid may worsen these CNS effects. The interaction is pharmacodynamic and incompletely studied.
How serious is the interaction between Remifentanil and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and falls, and use the lowest effective remifentanil dose.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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