Drug interactions
Remifentanil + Zolmitriptan
Severity: Minor
Remifentanil and Zolmitriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported when triptans are combined with serotonergic opioids. Remifentanil has little serotonergic activity, so the risk is low. Symptoms include agitation, tremor, hyperreflexia and hyperthermia.
What this interaction means in plain words
Remifentanil and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Remifentanil belongs to Musculoskeletal; Zolmitriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; theoretical for remifentanil.
What to do
Counsel on and monitor for symptoms of serotonin syndrome after dose changes. Stop the serotonergic drugs if features develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Remifentanil with Zolmitriptan?
MediHelp rates the interaction as minor. Remifentanil and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonin syndrome has been reported when triptans are combined with serotonergic opioids. Remifentanil has little serotonergic activity, so the risk is low. Symptoms include agitation, tremor, hyperreflexia and hyperthermia.
How serious is the interaction between Remifentanil and Zolmitriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on and monitor for symptoms of serotonin syndrome after dose changes. Stop the serotonergic drugs if features develop.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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