Drug interactions
Repaglinide + Somapacitan
Severity: Moderate
Repaglinide and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogs can reduce insulin sensitivity, which may weaken the glucose-lowering effect of repaglinide. Growth hormone may also induce CYP3A4 activity and modestly lower repaglinide exposure.
What this interaction means in plain words
Repaglinide and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone causes insulin resistance (pharmacodynamic antagonism) and may increase CYP450 activity.
What to do
Monitor blood glucose after starting somapacitan and increase the repaglinide dose if control worsens. Reassess if the growth hormone dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Repaglinide with Somapacitan?
MediHelp rates the interaction as moderate. Repaglinide and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone analogs can reduce insulin sensitivity, which may weaken the glucose-lowering effect of repaglinide. Growth hormone may also induce CYP3A4 activity and modestly lower repaglinide exposure.
How serious is the interaction between Repaglinide and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting somapacitan and increase the repaglinide dose if control worsens. Reassess if the growth hormone dose changes.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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