Drug interactions
Repaglinide + Somatrogon
Severity: Moderate
Repaglinide and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon, a growth hormone analog, can reduce insulin sensitivity and may raise blood glucose despite repaglinide. Growth hormone may also increase CYP450 activity and slightly lower repaglinide exposure.
What this interaction means in plain words
Repaglinide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone causes insulin resistance (pharmacodynamic antagonism) and may increase CYP450 activity.
What to do
Monitor blood glucose after starting somatrogon and increase the repaglinide dose if control worsens. Reassess when the growth hormone dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Repaglinide with Somatrogon?
MediHelp rates the interaction as moderate. Repaglinide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon, a growth hormone analog, can reduce insulin sensitivity and may raise blood glucose despite repaglinide. Growth hormone may also increase CYP450 activity and slightly lower repaglinide exposure.
How serious is the interaction between Repaglinide and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting somatrogon and increase the repaglinide dose if control worsens. Reassess when the growth hormone dose changes.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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