Drug interactions
Repaglinide + Spironolactone
Severity: Minor
Repaglinide and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is cleared substantially by CYP2C8 and CYP3A4. The claim that spironolactone inhibits CYP2C8 is not well established, so any rise in repaglinide exposure is uncertain.
What this interaction means in plain words
Repaglinide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Repaglinide belongs to Endocrine; Spironolactone belongs to Cardiovascular.
Why it happens
Possible weak CYP2C8 inhibition by spironolactone; not firmly established clinically.
What to do
No routine dose change is needed; monitor blood glucose when starting or stopping spironolactone and watch for hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Spironolactone?
MediHelp rates the interaction as minor. Repaglinide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide is cleared substantially by CYP2C8 and CYP3A4. The claim that spironolactone inhibits CYP2C8 is not well established, so any rise in repaglinide exposure is uncertain.
How serious is the interaction between Repaglinide and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood glucose when starting or stopping spironolactone and watch for hypoglycemia.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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