Drug interactions
Repaglinide + Triamcinolone
Severity: Moderate
Repaglinide and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and can offset the glucose-lowering effect of repaglinide, leading to poorer glycemic control. The effect is most evident with systemic or repeated depot injections and may persist for days to weeks.
What this interaction means in plain words
Repaglinide and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Triamcinolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: corticosteroids increase hepatic gluconeogenesis and induce peripheral insulin resistance.
What to do
Monitor blood glucose more frequently after triamcinolone administration and adjust the antidiabetic regimen as needed. Reassess the dose when the corticosteroid is reduced or stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Triamcinolone?
MediHelp rates the interaction as moderate. Repaglinide and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and can offset the glucose-lowering effect of repaglinide, leading to poorer glycemic control. The effect is most evident with systemic or repeated depot injections and may persist for days to weeks.
How serious is the interaction between Repaglinide and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after triamcinolone administration and adjust the antidiabetic regimen as needed. Reassess the dose when the corticosteroid is reduced or stopped to avoid hypoglycemia.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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