Drug interactions
Revefenacin + Trihexyphenidyl
Severity: Moderate
Revefenacin and Trihexyphenidyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Revefenacin is an inhaled long-acting antimuscarinic with low systemic exposure. Trihexyphenidyl may add to anticholinergic effects such as dry mouth, urinary retention and constipation.
What this interaction means in plain words
Revefenacin and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Revefenacin belongs to Respiratory; Trihexyphenidyl belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for systemic anticholinergic effects and urinary or glaucoma symptoms; reduce the trihexyphenidyl dose if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trihexyphenidyl
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Revefenacin with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Revefenacin and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Revefenacin is an inhaled long-acting antimuscarinic with low systemic exposure. Trihexyphenidyl may add to anticholinergic effects such as dry mouth, urinary retention and constipation.
How serious is the interaction between Revefenacin and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic anticholinergic effects and urinary or glaucoma symptoms; reduce the trihexyphenidyl dose if possible.
What other medicines interact with Trihexyphenidyl?
MediHelp also lists interactions of Trihexyphenidyl with, for example, Orphenadrin, Oxybutynin, Scopolamine. The full list is on the Trihexyphenidyl page.
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