Drug interactions
Indacaterol-glycopyrronium + Revefenacin
Severity: Major
Indacaterol-glycopyrronium and Revefenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Revefenacin is an inhaled long-acting muscarinic antagonist, as is glycopyrronium, so the two duplicate anticholinergic therapy. Combined use may increase dry mouth, urinary retention, constipation, glaucoma risk and tachycardia.
What this interaction means in plain words
Indacaterol-glycopyrronium and Revefenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Revefenacin belongs to Respiratory.
Why it happens
Additive antimuscarinic effects from two long-acting muscarinic antagonists.
What to do
Avoid using two long-acting anticholinergics together and pick a single LAMA-containing regimen. Monitor for anticholinergic effects if the overlap occurs during a switch.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol-glycopyrronium and Revefenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
- Darifenacin + Revefenacin Moderate
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Revefenacin?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Revefenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Revefenacin is an inhaled long-acting muscarinic antagonist, as is glycopyrronium, so the two duplicate anticholinergic therapy. Combined use may increase dry mouth, urinary retention, constipation, glaucoma risk and tachycardia.
How serious is the interaction between Indacaterol-glycopyrronium and Revefenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two long-acting anticholinergics together and pick a single LAMA-containing regimen. Monitor for anticholinergic effects if the overlap occurs during a switch.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
