Drug interactions
Atropine + Revefenacin
Severity: Moderate
Atropine and Revefenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Revefenacin is an inhaled long-acting antimuscarinic, and atropine is a systemic antimuscarinic. Together they may cause additive anticholinergic effects such as dry mouth, constipation, urinary retention, tachycardia and worsening of narrow-angle glaucoma.
What this interaction means in plain words
Atropine and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Revefenacin belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid giving other anticholinergics routinely with revefenacin. If atropine is needed, monitor for anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Benztropine + Revefenacin Moderate
- Darifenacin + Revefenacin Moderate
Frequently asked questions
Can I take Atropine with Revefenacin?
MediHelp rates the interaction as moderate. Atropine and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Revefenacin is an inhaled long-acting antimuscarinic, and atropine is a systemic antimuscarinic. Together they may cause additive anticholinergic effects such as dry mouth, constipation, urinary retention, tachycardia and worsening of narrow-angle glaucoma.
How serious is the interaction between Atropine and Revefenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving other anticholinergics routinely with revefenacin. If atropine is needed, monitor for anticholinergic toxicity.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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