Drug interactions
Ribociclib + Romidepsin
Severity: Major
Ribociclib and Romidepsin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may raise romidepsin levels, and both drugs can prolong the QT interval. The combination therefore increases the risk of romidepsin toxicity and arrhythmia.
What this interaction means in plain words
Ribociclib and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by ribociclib reduces romidepsin clearance, plus additive QT prolongation.
What to do
Avoid if possible; if combined, monitor ECG, potassium and magnesium and watch for romidepsin toxicity such as cytopenias and nausea.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Romidepsin?
MediHelp rates the interaction as major. Ribociclib and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib inhibits CYP3A4 and may raise romidepsin levels, and both drugs can prolong the QT interval. The combination therefore increases the risk of romidepsin toxicity and arrhythmia.
How serious is the interaction between Ribociclib and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, monitor ECG, potassium and magnesium and watch for romidepsin toxicity such as cytopenias and nausea.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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