Drug interactions
Ribociclib + Selumetinib
Severity: Major
Ribociclib and Selumetinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and can increase selumetinib concentrations, raising the risk of adverse effects such as gastrointestinal toxicity, rash and cardiomyopathy. Selumetinib labeling recommends dose reduction with CYP3A4 inhibitors.
What this interaction means in plain words
Ribociclib and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Selumetinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of selumetinib by ribociclib.
What to do
Prefer an alternative; if unavoidable, reduce the selumetinib dose per labeling and monitor for toxicity. Resume the prior dose after the inhibitor has been stopped for about three half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Ribociclib with Selumetinib?
MediHelp rates the interaction as major. Ribociclib and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib inhibits CYP3A4 and can increase selumetinib concentrations, raising the risk of adverse effects such as gastrointestinal toxicity, rash and cardiomyopathy. Selumetinib labeling recommends dose reduction with CYP3A4 inhibitors.
How serious is the interaction between Ribociclib and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative; if unavoidable, reduce the selumetinib dose per labeling and monitor for toxicity. Resume the prior dose after the inhibitor has been stopped for about three half-lives.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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