Drug interactions
Ribociclib + Sildenafil
Severity: Moderate
Ribociclib and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may increase sildenafil concentrations. Higher exposure can intensify hypotension and other sildenafil adverse effects.
What this interaction means in plain words
Ribociclib and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Sildenafil belongs to Genitourinary.
Why it happens
Ribociclib inhibits CYP3A4, reducing sildenafil clearance.
What to do
Use a lower starting sildenafil dose (e.g., 25 mg) and monitor blood pressure and tolerability. Ribociclib also prolongs QT, so review overall cardiac risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Sildenafil?
MediHelp rates the interaction as moderate. Ribociclib and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may increase sildenafil concentrations. Higher exposure can intensify hypotension and other sildenafil adverse effects.
How serious is the interaction between Ribociclib and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower starting sildenafil dose (e.g., 25 mg) and monitor blood pressure and tolerability. Ribociclib also prolongs QT, so review overall cardiac risk.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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