Drug interactions
Ribociclib + Sofosbuvir / velpatasvir
Severity: Minor
Ribociclib and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib could slightly increase velpatasvir exposure through CYP3A4 inhibition. Velpatasvir has a wide safety margin and several elimination routes, so a clinically important effect is unlikely.
What this interaction means in plain words
Ribociclib and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ribociclib inhibits CYP3A4, a minor contributor to velpatasvir metabolism.
What to do
No dose adjustment is required; monitor for tolerability of the antiviral regimen and for ribociclib adverse effects including QT prolongation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Ribociclib and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib could slightly increase velpatasvir exposure through CYP3A4 inhibition. Velpatasvir has a wide safety margin and several elimination routes, so a clinically important effect is unlikely.
How serious is the interaction between Ribociclib and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for tolerability of the antiviral regimen and for ribociclib adverse effects including QT prolongation.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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