Drug interactions
Ribociclib + Sufentanil sl
Severity: Major
Ribociclib and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
CYP3A4 inhibitors can increase sufentanil concentrations, and the sublingual product's labeling warns of potentially fatal respiratory depression with such combinations. Ribociclib is a moderate CYP3A4 inhibitor, so exposure may rise and effects may be prolonged.
What this interaction means in plain words
Ribociclib and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ribociclib inhibits CYP3A4, decreasing sufentanil clearance.
What to do
Monitor closely for respiratory depression and sedation, particularly at initiation, and consider an alternative analgesic if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Sufentanil sl?
MediHelp rates the interaction as major. Ribociclib and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. CYP3A4 inhibitors can increase sufentanil concentrations, and the sublingual product's labeling warns of potentially fatal respiratory depression with such combinations. Ribociclib is a moderate CYP3A4 inhibitor, so exposure may rise and effects may be prolonged.
How serious is the interaction between Ribociclib and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for respiratory depression and sedation, particularly at initiation, and consider an alternative analgesic if possible.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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