Drug interactions
Ribociclib + Teniposide
Severity: Moderate
Ribociclib and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teniposide is metabolized by CYP3A4, so ribociclib may increase its exposure and the risk of myelosuppression. Both agents can cause neutropenia, so overlapping toxicity may be clinically relevant.
What this interaction means in plain words
Ribociclib and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4-mediated metabolism of teniposide, and both agents have additive myelosuppressive effects.
What to do
Monitor complete blood counts closely and consider teniposide dose reduction or ribociclib interruption if severe neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Teniposide?
MediHelp rates the interaction as moderate. Ribociclib and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teniposide is metabolized by CYP3A4, so ribociclib may increase its exposure and the risk of myelosuppression. Both agents can cause neutropenia, so overlapping toxicity may be clinically relevant.
How serious is the interaction between Ribociclib and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and consider teniposide dose reduction or ribociclib interruption if severe neutropenia develops.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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