Drug interactions
Ribociclib + Tezacaftor
Severity: Moderate
Ribociclib and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tezacaftor is a CYP3A substrate, and its labeling advises a reduced dosing regimen with moderate CYP3A inhibitors. Ribociclib may raise tezacaftor exposure and increase adverse effects.
What this interaction means in plain words
Ribociclib and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing tezacaftor metabolism.
What to do
Use the reduced tezacaftor/ivacaftor regimen recommended for moderate CYP3A inhibitors, and monitor for adverse effects such as liver enzyme elevation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Tezacaftor?
MediHelp rates the interaction as moderate. Ribociclib and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tezacaftor is a CYP3A substrate, and its labeling advises a reduced dosing regimen with moderate CYP3A inhibitors. Ribociclib may raise tezacaftor exposure and increase adverse effects.
How serious is the interaction between Ribociclib and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced tezacaftor/ivacaftor regimen recommended for moderate CYP3A inhibitors, and monitor for adverse effects such as liver enzyme elevation.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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