Drug interactions
Ribociclib + Theophylline
Severity: Moderate
Ribociclib and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor and may modestly raise theophylline levels, though CYP3A4 is a minor pathway for theophylline. Ribociclib also prolongs the QT interval, which adds to theophylline's arrhythmogenic potential.
What this interaction means in plain words
Ribociclib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Ribociclib inhibits CYP3A4 and CYP1A2 may also be affected, reducing theophylline clearance, and it adds QT prolongation.
What to do
Monitor theophylline serum levels and ECG with electrolytes during combined use. Reduce the theophylline dose if levels rise or toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ribociclib and Theophylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Theophylline?
MediHelp rates the interaction as moderate. Ribociclib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a CYP3A4 inhibitor and may modestly raise theophylline levels, though CYP3A4 is a minor pathway for theophylline. Ribociclib also prolongs the QT interval, which adds to theophylline's arrhythmogenic potential.
How serious is the interaction between Ribociclib and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels and ECG with electrolytes during combined use. Reduce the theophylline dose if levels rise or toxicity appears.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
