Drug interactions
Ribociclib + Tiagabine
Severity: Moderate
Ribociclib and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tiagabine is extensively cleared by CYP3A4, so ribociclib may increase tiagabine levels. Higher exposure could produce dizziness, somnolence, tremor or, rarely, seizures.
What this interaction means in plain words
Ribociclib and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing the hepatic clearance of tiagabine.
What to do
Monitor for CNS adverse effects and seizure control, and lower the tiagabine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Tiagabine?
MediHelp rates the interaction as moderate. Ribociclib and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tiagabine is extensively cleared by CYP3A4, so ribociclib may increase tiagabine levels. Higher exposure could produce dizziness, somnolence, tremor or, rarely, seizures.
How serious is the interaction between Ribociclib and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects and seizure control, and lower the tiagabine dose if toxicity appears.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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