Drug interactions
Ribociclib + Tofacitinib
Severity: Moderate
Ribociclib and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may increase tofacitinib exposure. It also causes neutropenia, which adds to the infection risk of tofacitinib.
What this interaction means in plain words
Ribociclib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
CYP3A4 inhibition by ribociclib plus additive neutropenic and immunosuppressive effects.
What to do
Monitor neutrophil counts and signs of infection closely. Consider reducing the tofacitinib dose or interrupting it if neutropenia or infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Tofacitinib?
MediHelp rates the interaction as moderate. Ribociclib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may increase tofacitinib exposure. It also causes neutropenia, which adds to the infection risk of tofacitinib.
How serious is the interaction between Ribociclib and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection closely. Consider reducing the tofacitinib dose or interrupting it if neutropenia or infection develops.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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