Drug interactions
Ribociclib + Ulipristal
Severity: Moderate
Ribociclib and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal is metabolized mainly by CYP3A4, and ribociclib is a moderate-to-strong CYP3A4 inhibitor. Co-use may raise ulipristal exposure, although the clinical consequence of the short courses used for emergency contraception is uncertain.
What this interaction means in plain words
Ribociclib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing the metabolic clearance of ulipristal.
What to do
Avoid combining where practical and consider a non-hormonal emergency option such as a copper intrauterine device. Note that ribociclib patients require effective non-hormonal contraception in any case.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Ulipristal?
MediHelp rates the interaction as moderate. Ribociclib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ulipristal is metabolized mainly by CYP3A4, and ribociclib is a moderate-to-strong CYP3A4 inhibitor. Co-use may raise ulipristal exposure, although the clinical consequence of the short courses used for emergency contraception is uncertain.
How serious is the interaction between Ribociclib and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where practical and consider a non-hormonal emergency option such as a copper intrauterine device. Note that ribociclib patients require effective non-hormonal contraception in any case.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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