Drug interactions
Ribociclib + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Ribociclib and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a CYP3A4 substrate and ribociclib may increase its systemic exposure, potentially causing tachycardia, tremor and QT effects. Ribociclib also prolongs QT, so beta-agonist cardiovascular effects may be additive.
What this interaction means in plain words
Ribociclib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, raising vilanterol exposure, with additive QT effects.
What to do
Monitor heart rate, palpitations and ECG in patients with cardiac risk factors; use the inhaler at the labeled dose only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Ribociclib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a CYP3A4 substrate and ribociclib may increase its systemic exposure, potentially causing tachycardia, tremor and QT effects. Ribociclib also prolongs QT, so beta-agonist cardiovascular effects may be additive.
How serious is the interaction between Ribociclib and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, palpitations and ECG in patients with cardiac risk factors; use the inhaler at the labeled dose only.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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