Drug interactions
Ribociclib + Venlafaxine
Severity: Moderate
Ribociclib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and can modestly raise levels of venlafaxine through its minor CYP3A4 pathway. Both drugs can also prolong the QT interval, which adds arrhythmia risk.
What this interaction means in plain words
Ribociclib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus CYP3A4 inhibition by ribociclib that may modestly raise venlafaxine exposure.
What to do
Obtain a baseline ECG and electrolytes, and repeat the ECG after starting ribociclib. Monitor for venlafaxine adverse effects such as hypertension and serotonergic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Venlafaxine?
MediHelp rates the interaction as moderate. Ribociclib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and can modestly raise levels of venlafaxine through its minor CYP3A4 pathway. Both drugs can also prolong the QT interval, which adds arrhythmia risk.
How serious is the interaction between Ribociclib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes, and repeat the ECG after starting ribociclib. Monitor for venlafaxine adverse effects such as hypertension and serotonergic symptoms.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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