Drug interactions
Ribociclib + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Ribociclib and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may raise systemic exposure to inhaled fluticasone furoate and vilanterol, which depend on CYP3A4 for clearance. This may cause systemic corticosteroid effects and beta-agonist cardiovascular effects, including QT prolongation.
What this interaction means in plain words
Ribociclib and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing clearance of fluticasone furoate and vilanterol.
What to do
Monitor for cortisol suppression, tachycardia, hypokalemia and QT changes. Consider an alternative inhaler if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Ribociclib and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib may raise systemic exposure to inhaled fluticasone furoate and vilanterol, which depend on CYP3A4 for clearance. This may cause systemic corticosteroid effects and beta-agonist cardiovascular effects, including QT prolongation.
How serious is the interaction between Ribociclib and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cortisol suppression, tachycardia, hypokalemia and QT changes. Consider an alternative inhaler if symptoms occur.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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