Drug interactions
Ribociclib + Vincristine liposomal
Severity: Moderate
Ribociclib and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is a CYP3A4 substrate, and inhibition of this enzyme can raise exposure and increase neurotoxicity. Ribociclib is a moderate-to-strong CYP3A4 inhibitor at therapeutic doses, and both drugs can cause neutropenia.
What this interaction means in plain words
Ribociclib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, which may slow vincristine clearance, and both agents add to myelosuppression.
What to do
Monitor for peripheral neuropathy, constipation and neutropenia, and consider an alternative to ribociclib or dose reduction if neurotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Vincristine liposomal?
MediHelp rates the interaction as moderate. Ribociclib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vincristine is a CYP3A4 substrate, and inhibition of this enzyme can raise exposure and increase neurotoxicity. Ribociclib is a moderate-to-strong CYP3A4 inhibitor at therapeutic doses, and both drugs can cause neutropenia.
How serious is the interaction between Ribociclib and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and neutropenia, and consider an alternative to ribociclib or dose reduction if neurotoxicity develops.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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