Drug interactions
Ribociclib + Vorapaxar
Severity: Major
Ribociclib and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may increase vorapaxar exposure, and vorapaxar is a platelet inhibitor with a long half-life. Higher levels increase the risk of bleeding.
What this interaction means in plain words
Ribociclib and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ribociclib inhibits CYP3A4, which metabolizes vorapaxar.
What to do
Avoid the combination if possible and watch for signs of bleeding. Consider an alternative antiplatelet strategy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Vorapaxar?
MediHelp rates the interaction as major. Ribociclib and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib may increase vorapaxar exposure, and vorapaxar is a platelet inhibitor with a long half-life. Higher levels increase the risk of bleeding.
How serious is the interaction between Ribociclib and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and watch for signs of bleeding. Consider an alternative antiplatelet strategy.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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