Drug interactions
Ribociclib + Zaleplon
Severity: Minor
Ribociclib and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise zaleplon levels. Because CYP3A4 is only a secondary route for zaleplon, the increase is likely small, but sedation could be somewhat greater.
What this interaction means in plain words
Ribociclib and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ribociclib belongs to Oncology; Zaleplon belongs to Central Nervous System.
Why it happens
Ribociclib inhibits CYP3A4, reducing the minor oxidative clearance of zaleplon.
What to do
Monitor for increased sedation and next-day drowsiness; no dose adjustment is routinely required. Reduce the zaleplon dose if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Zaleplon?
MediHelp rates the interaction as minor. Ribociclib and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise zaleplon levels. Because CYP3A4 is only a secondary route for zaleplon, the increase is likely small, but sedation could be somewhat greater.
How serious is the interaction between Ribociclib and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and next-day drowsiness; no dose adjustment is routinely required. Reduce the zaleplon dose if excessive sedation occurs.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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