Drug interactions
Rifabutin + Roflumilast
Severity: Moderate
Rifabutin and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is a CYP inducer and may lower roflumilast exposure, possibly reducing its benefit in COPD. The effect is expected to be smaller than with rifampicin.
What this interaction means in plain words
Rifabutin and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Roflumilast belongs to Respiratory.
Why it happens
Induction of CYP3A4 and CYP1A2 increases roflumilast clearance.
What to do
Monitor COPD control and exacerbations during rifabutin therapy. Consider an alternative if effectiveness declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rifabutin and Roflumilast, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Roflumilast
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Roflumilast?
MediHelp rates the interaction as moderate. Rifabutin and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin is a CYP inducer and may lower roflumilast exposure, possibly reducing its benefit in COPD. The effect is expected to be smaller than with rifampicin.
How serious is the interaction between Rifabutin and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor COPD control and exacerbations during rifabutin therapy. Consider an alternative if effectiveness declines.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
