Drug interactions
Rifabutin + Secobarbital
Severity: Moderate
Rifabutin and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce rifabutin metabolism and lower its concentrations, potentially reducing antimycobacterial efficacy. The clinical consequence is likely modest but matters in serious infections.
What this interaction means in plain words
Rifabutin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 increases rifabutin clearance.
What to do
Monitor clinical response to rifabutin in tuberculosis or MAC therapy and consider drug level or dose review if response is poor. Prefer a non-inducing hypnotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Secobarbital?
MediHelp rates the interaction as moderate. Rifabutin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may induce rifabutin metabolism and lower its concentrations, potentially reducing antimycobacterial efficacy. The clinical consequence is likely modest but matters in serious infections.
How serious is the interaction between Rifabutin and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to rifabutin in tuberculosis or MAC therapy and consider drug level or dose review if response is poor. Prefer a non-inducing hypnotic if feasible.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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