Drug interactions
Rifabutin + Vinblastine
Severity: Moderate
Rifabutin and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may accelerate vinblastine clearance, possibly reducing its effect. Rifabutin is a weaker inducer than rifampicin, so the effect is likely smaller.
What this interaction means in plain words
Rifabutin and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Vinblastine belongs to Oncology.
Why it happens
Rifabutin induces CYP3A4 and increases the metabolism of vinblastine.
What to do
Monitor for reduced response to vinblastine. Where possible use a non-inducing alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Vinblastine?
MediHelp rates the interaction as moderate. Rifabutin and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may accelerate vinblastine clearance, possibly reducing its effect. Rifabutin is a weaker inducer than rifampicin, so the effect is likely smaller.
How serious is the interaction between Rifabutin and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to vinblastine. Where possible use a non-inducing alternative.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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