Drug interactions
Rifampicin + Selpercatinib
Severity: Major
Rifampicin and Selpercatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin markedly reduces selpercatinib exposure and may lead to treatment failure.
What this interaction means in plain words
Rifampicin and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Selpercatinib belongs to Oncology.
Why it happens
Strong CYP3A4 induction by rifampicin accelerates selpercatinib metabolism.
What to do
Avoid the combination and consider an alternative antimycobacterial regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Selpercatinib
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Selpercatinib?
MediHelp rates the interaction as major. Rifampicin and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin markedly reduces selpercatinib exposure and may lead to treatment failure.
How serious is the interaction between Rifampicin and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative antimycobacterial regimen.
What other medicines interact with Selpercatinib?
MediHelp also lists interactions of Selpercatinib with, for example, Amiodarone, Amisulpride, Amitriptyline. The full list is on the Selpercatinib page.
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