Drug interactions
Rifampicin + Trabectedin
Severity: Major
Rifampicin and Trabectedin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin lowers trabectedin exposure and may reduce antitumor efficacy.
What this interaction means in plain words
Rifampicin and Trabectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Trabectedin belongs to Oncology.
Why it happens
Strong CYP3A4 induction by rifampicin increases trabectedin metabolism.
What to do
Avoid concomitant use; choose a non-inducing alternative for the other indication.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trabectedin
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Trabectedin?
MediHelp rates the interaction as major. Rifampicin and Trabectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin lowers trabectedin exposure and may reduce antitumor efficacy.
How serious is the interaction between Rifampicin and Trabectedin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; choose a non-inducing alternative for the other indication.
What other medicines interact with Trabectedin?
MediHelp also lists interactions of Trabectedin with, for example, Apalutamide, Carbamazepine, Chloramphenicol. The full list is on the Trabectedin page.
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