Drug interactions
Rifampin + Rosuvastatin
Severity: Moderate
Rifampin and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Single-dose rifampin inhibits hepatic uptake of rosuvastatin and can raise its plasma concentrations, while repeated dosing has a smaller or mixed effect because of induction. The higher exposure may increase the risk of myopathy.
What this interaction means in plain words
Rifampin and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin inhibits OATP1B1-mediated hepatic uptake of rosuvastatin, raising systemic exposure.
What to do
Monitor for muscle symptoms and check creatine kinase if symptoms occur. Use the lowest effective rosuvastatin dose during rifampin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rifampin with Rosuvastatin?
MediHelp rates the interaction as moderate. Rifampin and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Single-dose rifampin inhibits hepatic uptake of rosuvastatin and can raise its plasma concentrations, while repeated dosing has a smaller or mixed effect because of induction. The higher exposure may increase the risk of myopathy.
How serious is the interaction between Rifampin and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and check creatine kinase if symptoms occur. Use the lowest effective rosuvastatin dose during rifampin therapy.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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