Drug interactions
Rifampin + Tizanidine
Severity: Moderate
Rifampin and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces drug-metabolizing enzymes and lowers tizanidine concentrations, which may reduce its antispasticity effect. The interaction is mainly a loss of efficacy rather than a toxicity risk, and it is manageable.
What this interaction means in plain words
Rifampin and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP enzymes including CYP1A2, increasing tizanidine clearance.
What to do
Monitor spasticity control and titrate tizanidine upward if needed. Reassess the dose when rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Rifampin with Tizanidine?
MediHelp rates the interaction as moderate. Rifampin and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces drug-metabolizing enzymes and lowers tizanidine concentrations, which may reduce its antispasticity effect. The interaction is mainly a loss of efficacy rather than a toxicity risk, and it is manageable.
How serious is the interaction between Rifampin and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spasticity control and titrate tizanidine upward if needed. Reassess the dose when rifampin is stopped.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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